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EX-4 in hGLP-1R mice (n = 57 per group, one-way ANOVA with Bonferroni post-tests)

It belongs to a novel class of drugs known as triple receptor agonists, meaning it simultaneously activates three distinct hormone receptors: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor

The most effective strategies are: Prioritising protein at each meal Aiming for regular resistance training (24 times per week if possible) Avoiding overly aggressive calorie restriction Ensuring overall diet quality despite reduced appetite These habits help signal the body to maintain muscle while losing fat