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6 Folate deficiency can negatively impact DNA repair in neurons, increasing vulnerability to oxidative stress and beta-amyloid toxicity, which can then lead to increased inflammation and higher risk of neurodegenerative diseases such as Alzheimers

A special committee investigation by the relevant institutions found that Leen Kawas (first author on Benoist 2014, co-author on McCoy 2013, and at the time CEO of the biotech commercializing a Dihexa derivative) had altered images in her doctoral dissertation and at least four published research papers from the Harding laboratory between approximately 2008 and 2012

Those are described as clinical decisions, not adjustments to make on your own

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What to Expect: Initial Effects and Dosage Adjustment: Some patients may notice a decrease in appetite within the first few days of starting the medication