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That made them a logical group of drugs to study in breast cancer populations, especially because preclinical work has suggested possible anticancer effects and because weight reduction itself may influence long-term outcomes

Reverse causality bias wasnt excluded

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Cortisol is a hormone that is released by the adrenal gland in response to stress, and it plays a role in a number of physiological processes, including glucose metabolism and immune system function

Beyond mouth ulcers, patients may experience: A sore, red, or swollen tongue (glossitis) Burning sensation in the mouth Altered taste perception Angular cheilitis (cracks at the corners of the mouth) Haematological manifestations arise from impaired red blood cell production

Results and treatment time may vary