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It is naturally synthesized within the cytosol of almost every cell in the body, with the highest concentrations found in the liver, lungs, and brain
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Oxidative stress, as reflected by glutathione status, appeared to be an earlier signal than inflammation in the trajectory of age-related cognitive decline
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The main difference between eryptosis and senescence of RBCs is the time constant of clearance, and it was shown that ionomycin-treated eryptotic mouse cells are cleared within minutes, whereas the clearance process of normal, healthy mouse erythrocytes takes several days [417]
Decreased BCL-2 protein and elevated Bax protein expression are other mechanisms leading to apoptosis by EGCG (Zhang et al., 2010a)
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