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It upregulates transcription of pro-osteoblastogenic growth factors including insulin-like growth factor 1 (IGF-1) and fibroblast growth factor 2 (FGF-2)

Dose may increase around this point

Retrieved from United States Pharmacopeia

Because they act on different receptors, the combination is studied for synergistic GH release greater than either category alone

Efficacy and safety of EMA401 in peripheral neuropathic pain: results of 2 randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy