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Additionally, this compound exhibits relatively long in vivo half-life characteristics, supporting once-daily dosing regimens and improving patient treatment compliance ( In rodent models, BI 1291583 demonstrated favorable dose-dependent NSP inhibitory effects

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Chen L, Na R, McLane KD, Thompson CS, Gao J, Wang X et al (2021) Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice

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