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Thus, in order to have GLP/GIP analogs with lasting effects, alterations of the peptides needed to be made in order to prevent their rapid metabolism by DPP-4 and oral administration could not be used

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FDA approval for its once-daily oral semaglutide (Wegovy) tablet, becoming the first oral GLP-1 receptor agonist approved for chronic weight management in adults with obesity or overweight conditions

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