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Soltani A, Ewe YP, Lim ZS, Sohal SS, Reid D, Weston S, Wood-Baker R, Walters EH

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Experimental studies have shown that Mg 2+ is a cofactor for the formation of C3 convertase, which is involved in the proteolytic activity of complement components, as well as in the binding of antigen to MF and the response to cytokines, the adhesion of Th and B cells, the synthesis of immunoglobulins, the binding of IgM with lymphocytes, ADCC (134)

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Moreover, BH4 can be regenerated by dihydrofolate reductase (DHFR)

An integrated map of genetic variation from 1,092 human genomes