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A 2024 pooled analysis of the SURMOUNT trials (Aronne et al., Lancet ) found that 4.3% of patients discontinued tirzepatide due to GI side effects

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To increase metabolite recovery, each well was washed with a further 750 l of cold methanol and pooled with the first sample

Pathmanathan, K., Robinson, P

The cohort included 15 cognitively healthy controls (HC), 17 patients with SCD, 14 patients with mild cognitive impairment (MCI), and 14 patients with dementia