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Advise women to inform their healthcare provider if they are pregnant or intend to become pregnant [see Use in SpecificPopulations (8.1), (8.3)]

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The consequences can include severe nausea, uncomfortable cramping, and in some cases, vomiting

Mild increases in left ventricular wall thickness, modest chamber enlargement, or isolated premature ventricular beats may reflect a multifactorial interplay between physiological training adaptation, pharmacologically mediated remodeling, and early pathological processes

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