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(2014, Nature Medicine) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure providing the foundational rationale for NNMT inhibition as a metabolic research target

These signals were diminished in the CMH@lip@TCeO 2 and CMH@lip@Res groups, and further reduced in the CMH@lip@Res-TCeO 2 group

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