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The general rule: shorter needle + pinch 90

Li W, Han J, Huang B, Xu T, Wan Y, Luo D

Uptake and metabolism of pyruvate and glucose by individual sheep preattachment embryos developed in vivo

Although the retro-inverso approach may fail to accurately reproduce biological function in the context of helical structures (e.g., p53 or HIV-1 proteins), certain exceptionssuch as the binding of a p53-derived retro-inverso peptide to its regulator MDM2demonstrate that well-designed D-peptides can, in specific cases, effectively mimic the function of the original peptide