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Administered as a once-weekly subcutaneous injection, tirzepatide has a half-life of approximately five days, allowing for sustained therapeutic effects

All gastrointestinal manifestations tend to improve with restauration of the euthyroid state

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For example, in clinical trials, nausea was reported in up to 44% of patients taking Wegovy at the maintenance dose

Studies showed a remarkable effect on people with obesity: The SELECT Trial found that MACE (major adverse CVD event) risk was reduced by 20% in adults with obesity without T2D in the group taking semaglutide

Dapagliflozin- induced severe ketoacidosis requiring hemodialysis