Spacing out dose frequency The Approach Spaced out dosing means extending the interval between GLP-1 injections beyond the approved schedule (for example, taking a weekly medicine less often than once a week)
We know that they are consuming fewer calories, but that doesn't mean that their nutritional needs change, Despain said
GLP-1s have been shown to reduce cravings for unhealthy foods and quiet ongoing thoughts about food
10.1161/JAHA.117.007339 308 SinkeA
This was not particularly surprising for researchers, as GLP-1 acts on the same brain regions that are involved in craving, reward, and motivation systems - largely driven by dopamine pathways
That said, we still dont have a clear answer on why this happens until semaglutide is tested on CVD patients without obesity.