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Progression to cirrhosis was observed in 3% and 4% of tirzepatide and placebo groups, respectively

Many enzymes of DNA replication and repair (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase use Fe as an indispensable cofactor for functioning (92)

Liraglutide was an exception as it also decreased the AUC [24]

doi:10.1016/j.molmet.2019.09.010 Mller TD, Finan B, Bloom SR, et al

Begin semaglutide therapy with a proactive hydration plan (100+ ounces of water daily), regular intake of potassium-rich foods, and magnesium glycinate supplementation (check dosing with your provider)

It is also released in response to cellular injury as an alarm signal whenever tissues are damaged