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Abbreviations ACEI: Angiotensin-converting enzyme inhibitors aHR: Adjusted hazard ratio AMI: Acute myocardial infarction ARB: Angiotensin II receptor blockers BMI: Body mass index CVD: Cardiovascular diseases CVOT: Cardiovascular outcome trial CI: Confidence interval CKD: Chronic kidney disease DM: Diabetes mellitus DPP-4i: Dipeptidyl peptidase-4 inhibitor eGFR: Estimated glomerular filtration rate ESKD: End-stage kidney disease GLP-1 RA: Glucagon-like peptide-1 receptor agonist HbA1c: Glycated hemoglobin HCOs: Healthcare organizations IQR: Interquartile range KTR: Kidney transplant recipient MACE: Major adverse cardiovascular events MAKE: Major kidney event PSM: Propensity score matching PTDM: Post-transplant diabetes mellitus RCTs: Randomized clinical trials SBP: Systolic blood pressure SD: Standard deviation SGLT2i: Sodium-glucose cotransporter 2 inhibitor SU: Sulfonylureas T2DM: Type 2 diabetes mellitus TZD: Thiazolidinediones References Rangaswami J, Mathew RO, Parasuraman R, Tantisattamo E, Lubetzky M, Rao S, Yaqub MS, Birdwell KA, Bennett W, Dalal P, et al

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Across all trials, 41 deaths occurred in individuals receiving tirzepatide ( n = 4573) and 39 in the comparator arms ( n = 2151)

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Finally, initial clinical trials indicated potentially higher rates of breast cancers and bladder cancers with dapagliflozin treatment, but these reports may have been artifacts of early vigilance

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