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10.1016/j.pneurobio.2019.101665 78 KaganV

GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

Improves sleep and boosts energy

For those dealing with systemic inflammatory conditions that manifest across multiple organs, KPV's mechanism is relevant beyond the gastrointestinal tract

Structure Therapeutics GSBR-1290 and Vikings VK2735 join a pipeline of small-molecule orals that promise comparable metabolic benefits with fewer GI events

Although preclinical studies in colon cancer models show that IDO1 inhibition can enhance T cell infiltration when combined with antiCTLA-4 therapy (125, 126), clinical trials of IDO1 monotherapy have demonstrated limited efficacy (127), reflecting tumor-specific metabolic adaptations and compensatory mechanisms