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A plausible explanation of this apparent dichotomy is that p53 promotes cell survival by preventing excessive increases in ROS under moderate oxidative stress, whereas when the oxygen species increase over a threshold level, it switches to becoming a ROS inducer, triggering cell death

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The hormone is normally broken down in the liver along with fat, however, when youre dieting your body is breaking up more fat than estrogen, leaving a lot more estrogen in the bloodstream than normal