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Retatrutide is a triple GLP-1, GIP, and glucagon receptor agonist under clinical investigation

Additionally, semaglutide improves insulin secretion in a glucose-dependent manner and reduces glucagon release, helping to stabilize blood glucose levels and reduce energy intake

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Patients who have tried semaglutide told Vox that it helped them manage their weight and relationship to food, and that their side effects were manageable and quickly resolved