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In a third trial, liraglutide significantly reduced weight by 8 pounds relative to placebo over 10 months in stable patients with bipolar disorder regardless of whether they were taking an antipsychotic (McElroy SL et al, J Clin Psychopharm 2024;44(2):8995)

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Cha S.J., Lee S., Choi H.J., Han Y.J., Jeon Y.M., Jo M., Lee S., Nahm M., Lim S.M., Kim S.H., et al

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Diagnosis is usually made in primary practice, but successful therapy is frequently hampered by the high frequency of side effects as well as patient noncompliance

A role for white matter abnormalities in the pathophysiology of bipolar disorder