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The situation is somewhat different in extracellular matrices, e.g., human plasma, where a substantial amount of SH is present as free cysteine, whereas GSH concentration is in the range of 2-20 M [2,3]

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The sustained eIF2 phosphorylation was confirmed in U3085 cells in which lobeline resulted in increased phosphorylated eIF2 up to 30 min post-hypoxia (Fig