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Notably, SPP1 + TAM showed an increased expression of VEGF and Syndecan-2 (SDC2) (69), a transmembrane proteoglycan that binds MMP-2, a metalloprotease released by endothelial cells upon hypoxic conditions ( SPP1 + TAM and tumor endothelial cells promotes tumor angiogenesis

2021;7(13): eabf9180

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