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Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, Hoes AW, Jennings CS, Landmesser U, Pedersen TR, Reiner Z, Riccardi G, Taskinen MR, Tokgozoglu L, Verschuren WM, Vlachopoulos C, Wood DA, Zamorano JL

Search strategy and study selection A systematic search was conducted up to November 2022 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA), to identify original studies from the PubMed database (PubMed, 2006) investigating GSH levels in (i) brain in vivo, using proton MRS ( 1 H-MRS) of healthy adults, or ex vivo biochemical analyses of autopsy tissue from people without neurological or psychiatric conditions in life, and/or (ii) blood from healthy adults using biochemical analyses of the fluid component (i.e., plasma or serum)

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Notably, the two clusters overexpressing Col1a1 and Col3a1 were significantly reduced after treatment

Hypotension and orthostatic hypotension were more frequently seen in patients on concomitant antihypertensive therapy